<i>Pseudomonas aeruginosa</i> phenazines dictate site-specific competitive interactions with <i>Klebsiella pneumoniae</i>.

ABSTRACT: Pseudomonas aeruginosa and Klebsiella pneumoniae are Gram-negative opportunistic pathogens that frequently colonize the human body and are major causes of infection. These bacteria are often co-isolated in polymicrobial urinary tract and lung infections, the latter of which is associated with increased disease severity and worse clinical outcomes. Despite their overlapping niches and clinical relevance, little is known about how these two pathogens interact and how those interactions influence human health. Given the growing recognition that microbial interactions are key drivers of disease, we investigated how P. aeruginosa and K. pneumoniae influence one another. We discovered an antagonistic interaction in which P. aeruginosa restricts the growth of

SUBMITTER: Todd K 

PROVIDER: S-EPMC12407999 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature