Mapping evolutionary paradigm of bovine viral diarrhea virus <i>Npro</i> associated with different organizations of nucleotide.

ABSTRACT: The non-structural protein (Npro) of bovine viral diarrhea virus (BVDV) is a crucial virulence factor that impairs the host's antiviral immune response and facilitates virus production. This study establishes a foundation for understanding how different selective pressures influence the formation of nucleotide pairs, synonymous codon, and context-dependent codon bias (CDCB) in BVDV Npro. BVDV genotype 1 exhibits a greater number of subgenotypes compared to other genotypes, yet its overall nucleotide usage bias in Npro is stronger. Within Npro, certain dinucleotides, specifically CpG and UpA, are notably suppressed, while UpG is selected with high frequency across all genotypes. The BVDV Npro region exhibits a pronounced bias in synonymous codon usage and possess

SUBMITTER: Feng X 

PROVIDER: S-EPMC12408059 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature