Kilohertz transcranial magnetic perturbation (kTMP) as a new non-invasive method to modulate cortical excitability.

ABSTRACT: Non-invasive brain stimulation (NIBS) provides a method for safely perturbing brain activity, and has been employed in basic research to test hypotheses concerning brain-behavior relationships with increasing translational applications. We introduce and evaluate a novel subthreshold NIBS method: kilohertz transcranial magnetic perturbation (kTMP). kTMP is a magnetic induction method that delivers continuous kHz-frequency cortical electric fields (E-fields) which may be amplitude modulated to potentially mimic electrical activity at endogenous frequencies. We used transcranial magnetic stimulation to compare the amplitude of motor-evoked potentials (MEPs) in a hand muscle before and after kTMP. In Experiment 1, we applied kTMP for 10 min over motor cortex to induce an E-field amplitude of a

SUBMITTER: Labruna L 

PROVIDER: S-EPMC12408067 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature