Exploration of the distribution of intestinal bacteria in mice under normal and intestinal leakage (IBD) conditions.

ABSTRACT: Introduction. The distribution of micro-organisms in healthy organisms remains a subject of debate. Emerging evidence revealed the colonization of microbial communities in multiple anatomical sites previously considered sterile under homeostatic conditions. However, the mechanistic relationship between compromised intestinal epithelial barrier integrity and subsequent translocation of gut-resident bacteria into systemic circulation has yet to be comprehensively elucidated.Hypothesis/Gap Statement. Under intestinal leakage, gut micro-organisms can break through the intestinal barrier and then translocate to other organs.Aim. This study investigates the distribution of micro-organisms in healthy organisms to determine whether gut bacteria translocate to sterile organs on

SUBMITTER: Niu J 

PROVIDER: S-EPMC12408187 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature