Xylene Impairs Neuronal Development by Dysregulating Calcium Homeostasis and Neuronal Activity in Developing Hippocampal Neurons.

ABSTRACT: Xylene is an aromatic hydrocarbon widely used as a solvent and emitted from numerous commercial products in industrial or indoor settings. Epidemiological studies of occupational exposure indicate that xylene primarily targets the central nervous system, producing neurobehavioral impairments and other neurological disorders. Both environmental and occupational exposure to volatile organic compounds, therefore, raise concerns about neurodevelopmental risk; however, the specific neurotoxicity of xylene in developing neurons remains poorly characterized. Here, we investigated the effects of xylene (2 or 5 mM) on developing mouse hippocampal neurons, with a focus on Ca²⁺ homeostasis, presynaptic function, and electrophysiological activity. We assessed Ca²⁺ homeostasis wit

SUBMITTER: Eom Y 

PROVIDER: S-EPMC12408200 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature