Case Report: Rare multisystem metastasis in head and neck paraganglioma with <i>SDHB</i> pathogenic variant and <i>KIF1B</i> VUS manifested as FUO.

ABSTRACT:

Background

Paragangliomas (PGLs) are rare neuroendocrine tumors originating from the extra-adrenal autonomic paraganglia with a strong genetic background. SDHB pathogenic variants are associated with the highest rate of malignancy in PGLs. Most head and neck paragangliomas (HNPGs) are asymptomatic and benign, and multiple metastases are rare.

Case presentation

A 37-year-old man presented at our hospital with a fever of unknown origin (FUO) without any other complaints except for mild consumption lasting over 6 months. Laboratory examinations showed elevated inflammatory markers (CRP, ESR, IL-6, and Ferritin) but no abnormalities in infection, immune, or tumor markers. Imaging examination found an oval-shaped space-occupying lesion in the right parapharyngeal space, wi

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12408261 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature