Association of high consumption of soy products with the risk of cognitive impairment and major neurocognitive disorders: a systematic review and dose-response meta-analysis.

ABSTRACT:

Objective

While soy products can potentially affect cognitive function through various mechanisms, the dose-response connection of high soy consumption with major neurocognitive disorder or cognitive impairment remains unclear.

Methods

A comprehensive retrieval was performed on PubMed, Embase, Cochrane Library, and Web of Science databases up to September 2024, to identify prospective or cohort studies (without language restrictions) examining the link between high soy consumption and the likelihood of developing major neurocognitive disorder or cognitive impairment. Stata (V15) was employed for data analysis, and a restricted cubic spline (RCS) model was employed for examining the dose-response effect.

Results

Six studies incorporating 68,691 participants were includ

SUBMITTER: Yu J 

PROVIDER: S-EPMC12408264 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature