Exercise interventions and serum IGF-1 levels in older adults with frailty and/or sarcopenia: a systematic review and meta analysis.

ABSTRACT:

Objective

Insulin-like growth factor-1 (IGF-1) is thought to play an important role in regulating skeletal muscle mass and function, with its decline potentially linked to age-related frailty and sarcopenia. Given the limitations of pharmacological and nutritional interventions, exercise may serve as a potential non-pharmacological strategy to modulate IGF-1 levels. The purpose of this study is to systematically evaluates the effects of exercise interventions on serum IGF-1 levels in older adults with frailty and/or sarcopenia using a meta-analysis approach.

Methods

A systematic search was conducted in PubMed, Web of Science, Cochrane Library, EMBASE and Scopus (from inception to July 2025) to identify randomized controlled trials (RCTs) investigating the impact of exercise

SUBMITTER: Chu R 

PROVIDER: S-EPMC12408309 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature