The effect of modulators on lung function following inpatient treatment for CF exacerbations.

ABSTRACT:

Background

Modulator therapy restores CFTR function and has led to health benefits for persons with cystic fibrosis (CF) (PwCF), including lower rates of pulmonary exacerbations. It is unknown if modulators affect lung function trajectories after inpatient treatment of pulmonary exacerbations (PEx).

Methods

We conducted a retrospective review of hospital encounters for PEx for subjects 6-25 years old with mild to moderate lung disease admitted to a large tertiary care center from 2014 to 2021 to capture hospitalizations of PwCF before and after starting modulators. Descriptive analyses were used to characterize the population and lung function findings. Logistic regression analyses were conducted to assess the association between modulators and FEV1pp outcomes.

Results

SUBMITTER: Stone A 

PROVIDER: S-EPMC12408314 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature