Spatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypes.

ABSTRACT: Intrinsic genetic alterations and dynamic transcriptional changes contribute to the heterogeneity of solid tumors. Lung adenocarcinoma (LUAD) is characterized by its significant histological, cellular and molecular heterogeneity. The present study aimed to study the spatial transcriptomics of primary LUAD with initial hopes to decipher molecular characteristics of subtype transitions in LUAD progression, offering new insights for novel therapeutic strategies. Spatial transcriptomics libraries were first generated from tumor samples collected from patients with LUAD who underwent surgical resection in The Fourth Hospital of Hebei Medical University in 2022 and were sequenced using Illumina NovaSeq 6000 system. The processed data were analyzed for differential gene expressions and networks,

SUBMITTER: Deng H 

PROVIDER: S-EPMC12408323 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature