Hypoxia promotes pancreatic adenocarcinoma progression by stabilizing ID1 via TRIM21 suppression.

ABSTRACT:

Introduction

Pancreatic adenocarcinoma (PAAD) is a highly aggressive malignancy characterized by a profoundly hypoxic tumor microenvironment, which fosters tumor progression and confers resistance to therapy The oncogenic regulator ID1has been implicated in PAAD malignancy, however, the mechanisms underlying hypoxia-induced stabilization of ID1 and the role of ubiquitin-mediated degradation remain poorly understood. Elucidating these pathways is essential for identifying novel therapeutic targets for PAAD.

Methods

In this study, we examined ID1 expression in PAAD tissues and cell lines using publicly available databases and in vitro models. We simulated hypoxic conditions to assess their effects on ID1 expression and tumor cell behaviors, including proliferation, migration,

SUBMITTER: Cheng R 

PROVIDER: S-EPMC12408324 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature