Associations of metabolic heterogeneity of obesity with the progression of cardiometabolic multimorbidity-a nationwide prospective cohort study.

ABSTRACT:

Background

Previous studies have demonstrated that both obesity and metabolic heterogeneity impact cardiovascular disease. However, the effect of different body mass index (BMI)-metabolic phenotypes on the progression of cardiometabolic multimorbidity (CMM) remains unclear.

Methods

This study utilized baseline data from the China Health and Retirement Longitudinal Study (CHARLS) in 2011, enrolling 5,850 participants for a longitudinal cohort analysis. Laboratory data from 2015 were used to assess 4,471 participants and evaluate the association between BMI-metabolic phenotype transitions (2011-2015) and the incidence of CMM. Participants were categorized into four BMI-metabolic phenotype groups: metabolically healthy normal weight (MHNW), metabolically healthy overweight/obes

SUBMITTER: Cai N 

PROVIDER: S-EPMC12408330 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature