The dynamics and geometry of choice in the premotor cortex.

ABSTRACT: The brain represents sensory variables in the coordinated activity of neural populations, in which tuning curves of single neurons define the geometry of the population code^1,2. Whether the same coding principle holds for dynamic cognitive variables remains unknown because internal cognitive processes unfold with a unique time course on single trials observed only in the irregular spiking of heterogeneous neural populations^3-8. Here we show the existence of such a population code for the dynamics of choice formation in the primate premotor cortex. We developed an approach to simultaneously infer population dynamics and tuning functions of single neurons to the population state. Applied to spike data recorded during decision-making, our model revealed that populations

SUBMITTER: Genkin M 

PROVIDER: S-EPMC12408350 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature