Collagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models.

ABSTRACT: Severe scarring is an inevitable consequence of large full-thickness skin wounds, often leading to long-term complications that affect patients' well-being and necessitate extended medical interventions. While autologous split-thickness skin grafts remain the clinical standard for wound treatment, they frequently result in contractures, excessive scarring, and the need for additional corrective procedures. To address these challenges, bioengineered skin substitutes capable of promoting efficient healing while reducing complications are highly desirable. Elastin, an essential component of the extracellular matrix, plays a crucial role in restoring tissue elasticity and regulating scar formation during wound healing. This study explores the impact of two distinct elastin-derived components,

SUBMITTER: Krymchenko R 

PROVIDER: S-EPMC12408406 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature