A novel fluorescent probe, triphenylamine rhodamine-3-acetic acid (mRA) for the detection of Amyloid-β aggregates in Alzheimer's disease.

ABSTRACT: Amyloid-β (Aβ) is implicated in the pathophysiology of Alzheimer's disease (AD) and plays a significant role in neuronal degeneration. Aβ in solution is essential during the initial stages of developing lead compounds that influence Aβ fibrillation. The tendency of the Aβ peptide to misfold in solution is correlated with the etiology of AD. Therefore, the early detection of Aβ serves as a critical foundation for diagnostic testing and routine clinical assessment of AD. Herein, an aggregation-induced fluorescence probe, triphenylamine rhodamine-3-acetic acid (mRA), was used to detect Aβ aggregates. The fluorescence results showed a strong interaction between the fluorescence probe mRA and Aβ aggregates. mRA specifically binds with high affinity to Aβ aggregates, and the limit of detection (

SUBMITTER: Chinnappan R 

PROVIDER: S-EPMC12408501 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature