2'-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity.

ABSTRACT:

Introduction

The development of new drugs for Alzheimer's disease (AD) remains a major challenge due to the disorder's complex and multifactorial nature. 2'-Fucosyllactose (2'-FL), a human milk oligosaccharide, has demonstrated promising neuroprotective properties. However, its effects on AD-related cognitive decline are not yet fully understood. This study aimed to investigate the therapeutic potential of 2'-FL in an aging mouse model of AD and to explore the underlying mechanisms involved.

Methods

5xFAD transgenic mice were treated with 2'-FL and assessed for cognitive function using the Morris water maze and Y-maze tests. Immunohistochemical staining was used to evaluate amyloid-beta (Aβ) and phosphorylated tau (p-tau) levels in brain tissue samples. Blood samples were an

SUBMITTER: Munni YA 

PROVIDER: S-EPMC12408522 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature