Dynamic brain network reconfiguration following rTMS in males with cocaine use disorder.

ABSTRACT: Cocaine use disorder (CUD) is characterized by cortico-striatal circuit dysregulation and high relapse rates, with repetitive transcranial magnetic stimulation (rTMS) emerging as a potential neuromodulatory intervention. This study investigates rTMS-induced dynamic brain network reconfigurations in 30 CUD patients using longitudinal resting-state fMRI from the SUDMEX-TMS cohort. Applying Leading Eigenvector Dynamics Analysis (LEiDA) to phase-locking states, we identified four metastable network configurations mapped to canonical resting-state networks. Post-rTMS analyses revealed selective modulation of visual network (VIS)-dominant states, showing increased duration and occupancy, alongside reduced self-transition probabilities in frontoparietal control network (FPCN) states after rTMS th

SUBMITTER: Le C 

PROVIDER: S-EPMC12408571 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature