Epigenetic modulation by life-style: advances in diet, exercise, and mindfulness for disease prevention and health optimization.

ABSTRACT: Socio-economic and environmental factors significantly influence health by driving epigenetic changes that alter genetic expression and impact disease prevention. Lifestyle elements such as diet, exercise, mindfulness, and environmental exposure play crucial roles in modulating these mechanisms. A systematic review of studies from the past 13 years, conducted under PRISMA guidelines, examined interventions, epigenetic outcomes, and health impacts. Mindfulness practices, particularly meditation, were found to regulate DNA methylation, reducing stress and inflammation. Dietary interventions, such as the Mediterranean and DASH diets, enhanced health biomarkers and slowed epigenetic aging through favorable DNA methylation. Physical activities, such as high-intensity interval training and hybri

SUBMITTER: Ostaiza-Cardenas J 

PROVIDER: S-EPMC12408607 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature