Antibodies against integrin αvβ6 have high diagnostic accuracy for ulcerative colitis.

ABSTRACT:

Background

Anti-integrin αvβ6 IgG autoantibodies showed good sensitivity and optimal specificity in ulcerative colitis (UC) compared to controls. We aim at confirming the diagnostic accuracy of anti-integrin αvβ6 autoantibodies in an Italian multicentric cohort.

Methods

This observational multicentric study included adult and pediatric patients with inflammatory bowel disease and controls. Data on demographics, disease extension, partial Mayo score, fecal calprotectin, endoscopic Mayo score, and the time to the composite outcome including hospitalization or colectomy were collected. A new commercial ELISA kit was used to measure anti-integrin αvβ6 in the serum of the enrolled patients. Receiver operating curve (ROC) was used to identify the optimal cutoff to discriminate UC

SUBMITTER: Bez P 

PROVIDER: S-EPMC12408611 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature