Quantification of neuroinflammation in spinal cord and neuroforamina of patients with painful cervical radiculopathy using [¹¹C]DPA713 PET/CT.

ABSTRACT:

Background

Animal models of nerve compression have revealed neuroinflammation not only at the entrapment site, but also remotely at the spinal cord. However, there is limited information on the presence of neuroinflammation in human compression neuropathies. The objectives of this study were to: (1) assess which tracer kinetic model most optimally quantified [¹¹C]DPA713 uptake in the spinal cord and neuroforamina in patients with painful cervical radiculopathy, (2) evaluate the performance of linearized methods (e.g., Logan) and simplified (e.g., standardized uptake value - SUV) methods, and (3) assess the test-retest reliability of these methods. Microglia activation associated with neuroinflammation was quantified using positron emission tomography (PET) with the radio

SUBMITTER: Lutke Schipholt IJ 

PROVIDER: S-EPMC12408627 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature