Effect of ketamine on cellular immunity and inflammation in patients who undergo laparoscopic colon cancer surgery: a retrospective study.

ABSTRACT:

Objective

Anesthesia during the surgery impairs immune systems. Ketamine is an anesthetic with immune protective effects. This study intended to investigate the effect of a ketamine-involved anesthetic regimen on cellular immunity and inflammatory cytokines in patients who undergo laparoscopic colon cancer surgery.

Methods

This retrospective study screened 60 patients who underwent laparoscopic colon cancer surgery with an anesthesia regimen involving ketamine (N = 30, ketamine group) or not (N = 30, opioid group). Data on surgery-related parameters, blood pressure, heart rate (HR), blood routine examination parameters, cluster of differentiation (CD) 3⁺ and CD4⁺ T cells, inflammatory cytokines, and adverse reactions were retrieved. Time points were def

SUBMITTER: Ji J 

PROVIDER: S-EPMC12408674 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature