Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer.

ABSTRACT:

Background

Growth hormone (GH) resistance is characterized by high GH levels but low levels of insulin-like growth factor-I (IGF-I) and growth hormone binding protein (GHBP) and, for patients with chronic disease, is associated with the development of cachexia.

Objectives

We investigated whether GH resistance is associated with changes in left ventricular (LV) mass (cardiac wasting) in patients with cancer.

Methods

We measured plasma IGF-I, GH, and GHBP in 159 women and 148 men with cancer (83% stage III/IV). Patients were grouped by tertile of echocardiographic LVmass/height² (women, < 50, 50-61, > 61 g/m²; men, < 60, 60-74, > 74 g/m²) and by presence of wasting syndrome with unintentional weight loss (BMI < 24 kg/m² and we

SUBMITTER: Frohlich AK 

PROVIDER: S-EPMC12408708 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature