Serum golgi protein-73 (GP-73) in children with autoimmune hepatitis.

ABSTRACT: To assess the correlation between serum Golgi protein-73 (GP-73) and the degree of hepatic fibrosis in children with autoimmune liver diseases. This case-control study included 100 children. Group A involved 50 children with autoimmune hepatitis (AIH), aged 2-17 years (mean 11.3 ± 2.7 years), while Group B included 50 age- and sex-matched healthy controls. All participants underwent clinical assessment, abdominal ultrasonography, laboratory investigations, and measurement of serum GP-73 using enzyme-linked immunosorbent assay. Children with AIH had significantly higher serum GP-73 levels than controls (median 110.7 ng/L vs. 21.3 ng/L, p < 0.001). GP-73 levels showed a strong positive correlation with both the histological activity index (r = 0.879, p < 0.001) and the stage of fibrosis (r =

SUBMITTER: Rizk MS 

PROVIDER: S-EPMC12408767 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature