TIMM8A-TIMM13 Complex Exerts Oncogenic Functions in Lung Cancer.

ABSTRACT:

Objectives

Lung cancer represents a major global healthcare challenge, characterized by high annual incidence and mortality rates worldwide. Although targeted therapies for lung cancer have advanced, treatment outcomes for advanced-stage patients remain suboptimal. This investigation examines the role of the translocase of the inner mitochondrial membrane (TIMM)8A-TIMM13 complex in lung cancer and evaluates its potential as a novel therapeutic target.

Methods

A co-immunoprecipitation (Co-IP) assay was conducted to verify the interaction between TIMM8A and TIMM13. Differential gene expression analysis of TIMM8A or TIMM13 was executed using the TNMplot database, with survival estimates derived from the Kaplan-Meier plotter. Lung cancer cell proliferation was evaluated through

SUBMITTER: Li S 

PROVIDER: S-EPMC12408856 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature