<i>MYH11</i> Suppresses Colorectal Cancer Progression by Inhibiting Epithelial-Mesenchymal Transition via <i>ZEB1</i> Regulation.

ABSTRACT:

Background

Colorectal cancer (CRC) is common and deadly, often leading to metastasis, challenging treatment, and poor outcomes. Understanding its molecular basis is crucial for developing effective therapies.

Aims

This study aimed to investigate the role of Myosin Heavy Chain 11 (MYH11) in CRC progression, especially its effects on epithelial-mesenchymal transition (EMT) and cell behavior, and to explore its potential regulation by the EMT transcription factor zinc finger E-box binding homeobox 1 (ZEB1).

Methods

Differential expression analysis was performed in the GSE123390 and TCGA-READ datasets, and 317 intersection genes were identified. The hub gene MYH11 was identified based on Protein-protein interaction (PPI) analysis and expression validation. The effects of

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12408857 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature