UHMK1 Promotes Prostate Cancer Progression through a Positive Feedback Loop with MTHFD2.

ABSTRACT:

Background

U2AF homology motif kinase 1 (UHMK1) has been associated with RNA processing and protein phosphorylation, thereby influencing tumor progression. The study aimed to explore its regulatory mechanisms and biological functions in human prostate cancer (PCa).

Methods

In this study, we systematically evaluated the expression and prognostic significance of UHMK1 in public databases, followed by validation through immunohistochemistry (IHC) in PCa specimens. Both gain-of-function and loss-of-function experiments were conducted to elucidate the role of UHMK1 in vitro and in vivo. Additionally, a series of molecular and biochemical assays were performed to investigate the regulatory mechanisms underlying UHMK1 activity.

Results

Our findings revealed tha

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12408860 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature