Acute pancreatitis gut dysbiosis persists at 1-year follow-up and is associated with clinical outcomes.

ABSTRACT:

Objectives

Pediatric acute pancreatitis (AP) is associated with gut dysbiosis. We aimed to determine if dysbiosis persisted during follow-up and whether it is associated with clinical outcomes.

Methods

Prospective enrollment of participants <21 years with first AP. Stool samples were obtained at baseline (n = 41), 3 months (n = 19), and 12 months (n = 12) and in healthy controls (HC; n = 34). Evaluation for diabetes (DM) or prediabetes (pre-DM) was performed. At 12-month follow-up gastrointestinal (GI) symptom surveys were completed and AP recurrence-acute recurrent pancreatitis (ARP) recorded. Shotgun metagenomic sequencing was performed on extracted microbial DNA.

Results

Microbial alpha diversity was lower for AP versus HC at all three time points (p < 0.008). Bray

SUBMITTER: Dike CR 

PROVIDER: S-EPMC12408973 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature