Utility of a noninvasive urine-based test for diagnosing acute pancreatitis in children.

ABSTRACT:

Objectives

Pediatric acute pancreatitis (AP) is a growing clinical concern with a wide spectrum of severity, from mild episodes to life-threatening conditions. Traditional diagnostic methods primarily rely on serum amylase and lipase measurements, which are invasive and can be challenging in children. This study is the first to evaluate the diagnostic accuracy of the urine trypsinogen-2 dipstick test (UTDT) as a noninvasive test for diagnosing pediatric AP.

Methods

This prospective study included 28 pediatric patients (31 episodes) presenting with acute abdominal pain at a tertiary medical center from November 2022 to October 2024. AP was diagnosed based on the International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE) criteria. Urine samples were c

SUBMITTER: Orgad T 

PROVIDER: S-EPMC12408976 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature