Does alendronate enhance survival rates in osteoporosis patients? A meta-analysis of randomized controlled trials.

ABSTRACT: ObjectivesThis systematic review and meta-analysis aims to evaluate whether alendronate therapy improves survival rates in patients with osteoporosis, in addition to its known benefits in reducing fracture risk.MethodsA comprehensive literature search was conducted across Embase, Web of Science, Medline, Cochrane Library, and ClinicalTrials.gov to identify randomized, placebo-controlled clinical trials involving alendronate therapy in osteoporosis patients. The primary outcome was overall survival. Data were extracted and analyzed using fixed-effects or random-effects models based on heterogeneity. The quality of evidence was assessed using the GRADE approach, and publication bias was evaluated using funnel plots.ResultsA total of 13 randomized controlled trials, involving 15,560 participa

SUBMITTER: Sun R 

PROVIDER: S-EPMC12408998 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature