The Change of Noncoding RNA Expression in Olfactory Bulb of Hepatic Encephalopathy Mouse Model: Transcriptomic Analysis and Cellular Analysis.

ABSTRACT:

Objectives

Hepatic encephalopathy (HE) is a neuropsychiatric disorder associated with cirrhosis and chronic liver disease primarily driven by ammonia (NH3) toxicity, which leads to neuroinflammation and cognitive deficits. Recent studies have identified olfactory dysfunction as a potential early indicator of HE, linked to ammonia-induced neurotoxicity in the brain.

Methods

After confirming physiological alterations in olfactory cells induced by ammonia, we assessed gene expression changes in olfactory bulbs of bile duct ligation (BDL) mice as an HE mouse model. We systematically profiled diverse coding and noncoding RNAs (ncRNAs) associated with olfactory dysfunction in HE and analyzed the functional implications based on transcriptomic signatures. We also compared ammonia t

SUBMITTER: Kim YK 

PROVIDER: S-EPMC12409072 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature