Tissue and Salivary NMR Metabolomics in Reticular-Type Oral Lichen Planus.

ABSTRACT: Oral lichen planus (OLP) is a chronic T-cell-mediated autoimmune disease, with low potential for malignant transformation. Its etiology remains unclear, necessitating immunohistochemical and molecular-level studies to enhance diagnosis and management. Thirteen patients diagnosed with OLP and 13 healthy controls (HCs) were enrolled from three centers. Mucosal tissue samples collected during diagnostic biopsies and unstimulated whole saliva samples were analysed. A comprehensive approach was taken, with high-resolution magic angle spinning (HR-MAS) ¹H-NMR spectroscopy performed on biopsies and liquid ¹H-NMR spectroscopy on saliva samples to identify potential biomarkers correlated with OLP. Multivariate analyses effectively distinguish OLP patients from HC based on meta

SUBMITTER: Setti G 

PROVIDER: S-EPMC12409093 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature