Cost-effectiveness of newborn screening for severe combined immunodeficiency: a systematic review.

ABSTRACT: Severe combined immunodeficiency (SCID) is a rare genetic disorder that causes severe infections and death in early childhood. Newborn bloodspot screening (NBS) for SCID using the T-cell receptor excision circle assay can revolutionize the early detection and treatment of infants with SCID, leading to improved quality of life and life expectancy. This systematic review aimed to examine the cost-effectiveness of universal NBS for SCID. The MEDLINE, Embase, National Health Service (NHS) Economic Evaluation Database, Health Technology Assessment, Scopus, and EconLit databases were searched for studies of the NBS for SCID published between January 2008 and March 2024. A standardized data extraction form was used to gather pertinent data such as characteristics, design, perspective, screening s

SUBMITTER: Rana R 

PROVIDER: S-EPMC12409193 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature