Effects of pioglitazone with and without exercise training on cardiorespiratory fitness and oxygen uptake kinetics in type 2 diabetes.

ABSTRACT:

Aims

Exercise tolerance is often impaired in type 2 diabetes (T2D), and barriers to regular exercise are common. This study evaluated whether 12 weeks of pioglitazone (PIO) therapy could enhance peak oxygen uptake (V̇O_2peak) and the time constant of the primary phase of oxygen uptake (τV̇O_2p) during submaximal exercise, compared with exercise training, and whether combining PIO with exercise would provide additional benefits in T2D.

Materials and methods

Male participants with T2D were assigned to one of the following groups: (1) non-exercising control (CON, n = 12), (2) PIO (15 mg/day) alone (PIO, n = 6), (3) exercise training alone (EXC, n = 13), or (4) PIO combined with exercise (PIO + EXC, n = 7). Exercise involved aerobic and resistance training th

SUBMITTER: O'Connor E 

PROVIDER: S-EPMC12409202 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature