YTHDC2 inhibits HPV-positive cervical cancer growth by suppressing SLC7A11 in a ferroptosis-dependent manner.

ABSTRACT: Chronic infection with high-risk human papillomavirus (HPV) types increases the risk of developing cervical cancer (CC). Notably, these HPV types are implicated in ~70% of all CC cases. YTH N6-methyladenosine RNA-binding protein C2 (YTHDC2) is an N6-methyladenosine reader associated with several cancers, although its specific function in CC remains poorly understood. The present study aimed to elucidate new functions of YTHDC2 in HPV-positive CC cell proliferation and ferroptosis, mediated by pathways dependent on protein synthesis. A comparative analysis revealed reduced levels of YTHDC2 in HPV-positive CC samples and cell lines compared with those in HPV-negative samples. YTHDC2 overexpression diminished cell viability and proliferation, whereas silencing YTHDC2 enhanced these processes,

SUBMITTER: Ren L 

PROVIDER: S-EPMC12409215 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature