The impact of plasma glucose decline rate on cardiac repolarisation in individuals with type 1 diabetes.

ABSTRACT:

Aims

To investigate whether plasma glucose decline rates influence cardiac repolarisation, transmural dispersion and counterregulatory hormones in individuals with type 1 diabetes (T1D) with and without good glycaemic control.

Materials and methods

In a randomised crossover study, 20 young men with T1D (10 well-regulated (HbA1c ≤53 mmol/mol); 10 dysregulated (HbA1c ≥63 mmol/mol)) underwent two separate glucose clamps involving either a rapid (Clamp-rapid) or slow (Clamp-slow) decline in plasma glucose from hyperglycaemia (baseline) (15 mmol/L) to euglycaemia (5 mmol/L). Changes in cardiac repolarisation (QTc interval), transmural dispersion (measured as the T-peak to T-end interval (Tpe interval)) and counterregulatory hormones were assessed. Study outcomes were primarily co

SUBMITTER: Hagelqvist PG 

PROVIDER: S-EPMC12409222 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature