Quality assurance and reporting for FLASH clinical trials: The experience of the FEATHER trial.

ABSTRACT:

Background

Research on ultra-high dose rate (UHDR) radiation therapy has indicated its potential to spare normal tissue while maintaining equivalent tumor control compared to conventional treatments. First clinical trials are underway. The randomized phase II/III FEATHER clinical trial at the Paul Scherrer Institute in collaboration with the University of Zurich Animal Hospital is one of the first curative domestic animal trials to be attempted, and it is designed to provide a good example for human trials. However, the lack of standardized quality assurance (QA) guidelines for FLASH clinical trials presents a significant challenge in trial design.

Purpose

This work aims to demonstrate the development and testing of QA and reporting procedures implemented in the FEATHER clin

SUBMITTER: Colizzi I 

PROVIDER: S-EPMC12409223 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature