Impact of eligibility for diabetes remission on response to intensive lifestyle intervention in overweight and obese people with type 2 diabetes: The Look AHEAD trial.

ABSTRACT:

Aims

To achieve remission of type 2 diabetes, resources to support intensive lifestyle intervention (ILI) are directed toward people with diabetes for whom remission is achievable, that is, people with short diabetes duration and lower HbA1c. We aimed to determine if responses to ILI, other than remission, justify this resource allocation.

Materials and methods

We analysed participants from the Look AHEAD randomised controlled trial who were 20-65 years old with a BMI of 27-45 kg/m². The effect of ILI was assessed after stratification for remission eligibility at baseline (diabetes duration ≤6 years and no insulin therapy). Cox proportional hazards models evaluated the effect of ILI on incident CVD, chronic kidney disease (CKD), and mortality. Linear models with g

SUBMITTER: Gong JY 

PROVIDER: S-EPMC12409236 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature