N-lactoyl amino acids are potential biomarkers for insulin resistance and diabetic complications.

ABSTRACT:

Aims

N-lactoyl amino acids (Lac-AA) are emerging as crucial players in metabolic research, with potential implications for disease mechanisms and therapeutic interventions. This study exploress the role of Lac-AA in insulin resistance, type 2 diabetes (T2D), and its complications.

Materials and methods

A cross-sectional study was conducted using data from 2918 participants from Qatar Biobank. After quality control, 2907 individuals were retained and randomly divided into discovery (n = 1990) and validation (n = 917) cohorts. Untargeted metabolomics was employed to profile serum metabolites, and analysis was focused on three Lac-AA species. Participants were stratified into insulin-sensitive, insulin-resistant, T2D without complications and T2D with complications. Association

SUBMITTER: Naja K 

PROVIDER: S-EPMC12409262 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature