PGC-1α-mediated mitochondrial homeostasis imbalance aggravated gingival lesions of diabetic periodontitis by disrupting ECM remodeling of human gingival fibroblast.

ABSTRACT: Diabetic periodontitis (DP) usually has more severe clinical symptoms compared with chronic periodontitis (CP), especially the worsened gingival lesions. Mitochondrial homeostasis plays an important role in both diabetes and periodontitis, and some studies have already confirmed its role in DP. However, there are few reports on whether mitochondrial homeostasis is involved in regulating DP gingival lesions. In this study, we focused on the pathological changes of the gingival connective tissues from DP and identified the extracellular matrix (ECM) pathway as the key regulatory pathway. Additionally, we found that the pathological changes in DP gingiva were accompanied by significant alterations in the morphology and structure of cellular mitochondria. We discovered that the regulatory mole

SUBMITTER: Huang J 

PROVIDER: S-EPMC12409324 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature