Circulating particles carotenoids are associated with rehabilitation recovery in Parkinson's disease.

ABSTRACT: Circulating nanoparticles include Extracellular Vesicles (EVs) and other circulating EV-like particles that are known mediators of the trafficking of pathologic proteins associated with Parkinson's disease (PD) progression as well as of products of the oxidative damage that characterizes the disease. In the framework of the VIRTREAD-PD trial protocol, circulating particles were isolated from the serum of 30 subjects with PD before and after an intensive rehabilitation program using a treadmill. Raman spectroscopy was used to verify modifications in the biochemistry of circulating particles and proved that an intensive motor rehabilitation program could affect the molecular composition of EV-like particles in the blood of people with PD (pwPD). Analysis performed before and after 8 weeks of

SUBMITTER: Gualerzi A 

PROVIDER: S-EPMC12409329 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature