Platelet dynamics and thrombocytopenia in dengue fever: A prospective cohort study from Shenzhen, China.

ABSTRACT:

Introduction

Dengue fever, the most prevalent arthropod-borne viral disease, causes ∼400 million infections annually. Although thrombocytopenia is commonly associated with dengue, how it evolves in relation to viral load and immune responses remains poorly understood. This study aimed to elucidate platelet-virus-immune interactions in acute dengue by systematically tracking of viral load, platelet parameters, and leukocyte dynamics.

Methods

A prospective cohort study was conducted at Third People's Hospital in 2024, involving 135 confirmed dengue cases, supported by retrospective data from 2014 to 2023. Platelet counts, hematocrit (HCT), and cellular immunity markers (lymphocyte/neutrophil percentages) were longitudinally tracked. Viral load was quantified via NS5 gene Ct va

SUBMITTER: Guo L 

PROVIDER: S-EPMC12409373 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature