Genome-wide association study identifying immune markers in Qingyuan partridge chickens infected with avian Leukosis virus subgroup J.

ABSTRACT: In poultry, Avian Leukosis Virus (ALV) causes high mortality and significant eradication costs, with no effective vaccines, hindering industry development. Improving resistance to ALV-J offers both economic and ecological value. The Qingyuan Partridge Chickens is a high-quality, possesses certain disease resistance capabilities. This study explored resistance molecular markers in Qingyuan Partridge Chickens through cell experiments, viral infection, and genomic resequencing. Results showed that interferon-alpha (IFN-α) expression significantly suppressed the ALV-J duplicated, with notable immune response differences between sexes. Genome-wide association study (GWAS) identified 62 single nucleotide polymorphisms (SNPs) linked to immune responses, cloacal viral positivity, and tissue indice

SUBMITTER: Jie H 

PROVIDER: S-EPMC12409427 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature