<i>Akkermansia muciniphila</i> Alleviates Sarcopenia in Senescence-Accelerated Mouse-Prone 8 Mice.

ABSTRACT: Akkermansia muciniphila, an intestinal bacterium, has garnered attention for its association with metabolic health and anti-inflammatory properties. However, its potential role in mitigating sarcopenia, particularly in the senescence-accelerated mouse-prone 8 (SAMP8) model, remains unexplored. In this study, we aimed to evaluate the potential effects of A. muciniphila supplementation on sarcopenia and its underlying mechanisms. Seven-month-old SAMP8 mice were administered A. muciniphila for 3 months. A. muciniphila supplementation enhanced grip strength and skeletal muscle mass, suppressed cellular senescence, improved the balance between protein degradation and synthesis, increased total ATP, and improved mitochondrial biogenesis. Analysis of the effects of

SUBMITTER: Park SH 

PROVIDER: S-EPMC12409435 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature