Feasibility of the omission of axillary surgery in node-negative early breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Recent and historical trials have suggested that the omission of axillary surgery is oncologically safe in node-negative early breast cancer. This meta-analysis investigates the feasibility of the omission of axillary surgery (SLNB or ALND) in terms of oncological outcomes and adjuvant treatment decisions.

Method

A systematic search of Medline, Embase and Cochrane Central was conducted. Random-effect meta-analysis was conducted to compare recurrence and survival outcomes between omission of axillary surgery and SLNB or ALND. Differences in real-world adjuvant treatment decisions and patient reported outcomes were investigated.

Results

Ten studies (omission, n = 3716; SLNB/ALND, n = 4604/785) investigated oncological outcomes (pooled rates, T1 88 %; Grade

SUBMITTER: Lucocq J 

PROVIDER: S-EPMC12409457 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature