Associations of cardiovascular health with arterial health in adults free of cardiovascular disease.

ABSTRACT:

Background

In adults without cardiovascular disease (CVD), there is limited understanding of the association between overall cardiovascular health (CVH) and arterial health.

Methods

In 2330 Framingham Heart Study Offspring participants free of CVD (60±9 years; 57% women) with Life's Essential 8 (LE8) and applanation tonometry data (Exam 7), we calculated CVH scores per American Heart Association's LE8 guidelines. Multivariable-adjusted regression analyses examined the relations of LE8 with aortic stiffness and pressure pulsatility [negative inverse carotid-femoral pulse wave velocity (niCFPWV), central pulse pressure (CPP), respectively], and examined effect modification by age and sex. We also evaluated niCFPWV and CPP as mediators of the relation between LE8 and death outc

SUBMITTER: Jha M 

PROVIDER: S-EPMC12409459 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature