Reconstructing patient level survival data from published Kaplan-Meier curves.

ABSTRACT:

Introduction

Individual-level patient data (IPD) are helpful for designing clinical trials, conducting meta-analyses, or methodology research. However, such patient level data are not readily available. Multiple methods have been developed for reconstructing survival data using published Kaplan-Meier (KM) survival curves. There has been no practical guidance on an optimal approach or extensive evaluation of the performance of the approach.

Methods

We reviewed several methods of extracting the coordinates of KM survival curves and reconstructing individual-level survival data. Then, we reproduced data from 46 published KM curves. The accuracy of reconstructed data is quantified by comparing hazard ratios (HRs) and their confidence intervals (CIs) estimated from the reproduced

SUBMITTER: Kim J 

PROVIDER: S-EPMC12409465 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature