Identification of Phialomustin‑B (PHL-B) as a Novel Natural TRPA1 Channel Inhibitor.

ABSTRACT: The TRPA1 channel has recently emerged as a critical target for pain relief since its antagonists target the beginning of the pain transduction pathway and, thus, are devoid of side effects such as sedation, dizziness, somnolence, or cognitive impairment. Despite this clinical significance, currently, no TRPA1 inhibitors suitable for therapeutic usage exist to target these channels. Since ancient times, natural products have been known to be a rich source of new drugs, useful therapeutic agents, as well as pharmacological tools. To discover novel natural TRPA1 antagonists, we screened a diverse range of natural products belonging to medicinal plants and endophytic microbes. Using a fluorescence-based calcium-influx assay, we identified that an unsaturated fatty acid known as Phialomustin B

SUBMITTER: Yadav P 

PROVIDER: S-EPMC12409571 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature