Functional Connectivity Predicting Transdiagnostic Treatment Outcomes in Internalizing Psychopathologies.

ABSTRACT:

Importance

Predicting treatment outcomes for internalizing psychopathologies (IPs), such as depression and anxiety, holds promise for advancing precision medicine. The extent to which whole-brain functional connectivity (FC) can predict treatment responses for patients with IPs across different therapeutic modalities remains unclear.

Objective

To examine whether pretreatment FC patterns predict multidimensional treatment outcomes in patients with IPs and whether predictive performance generalizes across diagnoses and treatment modalities.

Design, setting, and participants

This prognostic study analyzed baseline neuroimaging and clinical data from patients with IPs enrolled in 1 of 2 randomized clinical trials (conducted from December 2013 to February 2018 and Septembe

SUBMITTER: Zhang K 

PROVIDER: S-EPMC12409597 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature