Acinetobacter baumannii as a Model for the Study and Application of Gram-Negative Outer Membrane Vesicles: A Systematic Review.

ABSTRACT: Outer membrane vesicles (OMVs) are extracellular nanostructures released from Gram-negative bacteria. Acinetobacter baumannii OMVs (AbOMVs) have been extensively studied and can thus be used as a model for understanding multiple aspects of OMV biology. In this systematic review, we comprehensively assess the relevant literature covering AbOMVs and present these studies in the context of OMV biology in general. An overview of current knowledge regarding AbOMV biogenesis is presented, focusing on the cellular, intrinsic and extracellular factors that induce AbOMV production. In addition, the components that form the AbOMVs, with an emphasis on protein content, are described. Different methodologies that have been used to isolate and purify the AbOMVs for different studies and applications ar

SUBMITTER: Cano-Castano B 

PROVIDER: S-EPMC12409660 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature