Overexpression of adipose tissue ERα enhances PVAT anticontractility via NOX4-derived H₂O₂ and is protective against high-fat diet-induced dysfunction.

ABSTRACT: Menopause has unequivocally been associated with cardiovascular risk and obesity. Loss of estrogen bioavailability is a hallmark of menopause. Estrogen is generally considered vasculoprotective, with estrogen receptor α (ERα) being the predominant receptor subtype that mediates these positive effects. Similarly, estrogen and ERα are known to stimulate white adipose tissue metabolism. However, it is unknown whether ERα could exert a beneficial effect on mesenteric perivascular adipose tissue (PVAT). PVAT is a heterogeneous tissue that surrounds most peripheral blood vessels. In physiological conditions, PVAT has an anticontractile effect on the vasculature. However, in several diseases, PVAT switches its phenotype to become procontractile. To date, the role of ERα in PVAT function in health

SUBMITTER: Costa TJ 

PROVIDER: S-EPMC12409677 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature